Graminex - Products containing Flower Pollen Extract - Clinical evaluation of long-term treatment using Cernitin ™ pollen extract in patients with benign prostatic hyperplasia

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Clinical evaluation of long-term treatment using Cernitin ™ pollen extract in patients with benign prostatic hyperplasia

Yasumoto R, Kawanishi H, Tsujino T, Tsujita M, Nishisaka N, Horii A, Kishimoto T

Seventy-nine patients with benign prostatic hyperplasia (BPH) were treated with Cernitin ™ pollen extract. Patient ages ranged from 62 to 89 years (mean, 68 years). Mean baseline prostatic volume was 33.2 cm3. Cernitin ™ pollen extract was administered in a dosage of 126 mg (2 tablets, 63 mg each), three times a day, for more than 12 weeks. Symptom scores, based on a modified Boyarsky scoring scale, uroflowmetry, prostatic volume, residual urine volume, and urinalysis results were examined before and after administration of Cernitin ™ pollen extract. Symptom scores significantly decreased from baseline, and the favorable results continued during the treatment period. Urine maximum flow rate and average flow rate increased significantly from 9.3 mL/s to 11 mL/s and from 5.1 mL/s to 6 mL/s, respectively. Residual urine volume decreased significantly from 54.2 mL to less than 30 mL. There was no change in prostatic volume. However, 28 patients treated for more than 1 year showed a mean decrease of prostatic volume to 26.5 cm3. No adverse reactions were observed. Clinical efficacy at 12 weeks was rated excellent, good, satisfactory, and poor in 11%, 39%, 35%, and 15% of patients, respectively. Overall clinical efficacy was 85%. In conclusion, Cernitin ™ pollen extract showed a mild beneficial effect on prostatic volume and urination variables in patients with symptomatic BPH.

PMID: 7538904, UI: 95277792

Department of Urology and Andrology
Osaka Municipal Juso Citizens' Hospital, Japan

Clin Ther 1995 Jan-Feb;17(1):82-7