Graminex - Products containing Flower Pollen Extract - Alterations in the Intraprostatic Hormonal Metabolism by the Pollen Extract Cernilton ®

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Alterations in the Intraprostatic Hormonal Metabolism by the Pollen Extract Cernilton ®

Sabine Tunn, M. Krieg

Introduction

A number of hypotheses have been implicated in the etiology of benign prostatic hyperplasia (BPH). The most important theories are: (1) an alteration of the androgen metabolism in BPH if compared to the normal prostate (NPR) leading to an accumulation of the biologically highly active androgen 5a-dihydrotestosterone (DHT) predominantly in the stroma; (2) a change in the androgen-estrogen ratio in favor of estrogens; (3) and an alteration in the intraprostatic interaction between stroma and epithelium. Such variable hypotheses do not allow a unified therapeutic concept for BPH. For the medical treatment of BPH a variety of substances are utilized such as GnRH analogues, which reduce peripheral androgen and estrogen concentration, 5a-reductase inhibitors, which lower the intraprostatic DHT concentration, or aromatase inhibitors, which lower the peripheral estrogen concentration. Read the Full Study

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